Welcome to the Deshpande Lab
Welcome to the Deshpande Lab

Under the purview of the DOD Gulf-War Illness Research Program and the NIH CounterACT Research Program, we are identifying calcium-signaling based therapeutics for the neurological consequences of pesticide exposures. My laboratory is committed to scientific education and research and we welcome students and investigators who would like to partner with us on this mission.

Lab/ Office:

Kontos Medical Sciences Bldg.

Room-615

1217 E. Marshall St.

Richmond, VA 23298

Tel: 804-828-3392

Email: Laxmikant.Deshpande@vcuhealth.org

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Current Events

The Alzheimer's and Related Diseases Research Award Fund (ARDRAF) has selected our proposal, "Assessment of Beta-site amyloid precursor protein cleaving enzyme 2 (BACE2) in a rat model of occupational-like organophosphate pesticide exposure" for 2022-2023 award cycle. This project is in collaboration with Dr. McClay, VCU School of Pharmacy.

As part of implementing the One VCU Research Strategic Priorities Plan, our proposal, "Single-cell gene expression analysis of organophosphate neurotoxicity in the hippocampus," has been selected for a VCU Quest Fund award for 2022 cycle. This project is in collaboration with Dr. McClay, VCU School of Pharmacy.

Dr. Ribeiro presented data on the development of a chronic depression-like condition following occupational level exposure to pesticide chlorpyrifos during adulthood at the 61st SOT meeting. The accompanying paper was published in Neurotoxicology

Deshpande-McClay lab received a pilot grant from VCU PMDC for studying role of epigenetics in a rat model for environmentally-induced Parkinson's Disease

Our review of pre-clinical models for Gulf War Illness has been published in Pharmacology & Therapeutics

Our paper with McClay lab provides evidence for chronic epigenetic histone alterations and its alleviation by valproic acid therapy in a rat model of Gulf War Illness.